In general the risk of seizures due to bupropion is low. The risk of having a seizure increases with higher than recommended doses of bupropion, a history of seizures or head injury, tumor in the brain, severe liver disease, an eating disorder, alcohol or drug dependence, or taking other drugs that can also increase your risk of having a seizure.
There is a low risk of cardiovascular adverse events associated with stimulating agents, including bupropion. This risk increases if you have heart disease, high blood pressure, previous heart attack, or irregular heartbeat, or when used with transdermal nicotine replacement products.
In these cases, a thorough cardiovascular evaluation is recommended before starting this medicine. To date, there are no known problems associated with long term use of bupropion. It is a safe and effective medication when used as directed. Bupropion should not be taken with or within two weeks of taking monoamine oxidase inhibitors MAOIs. There are several products with the active ingredient bupropion. Do not take more than one product that contains bupropion since this may increase your risk of having a seizure.
Certain medications may increase your risk of having a seizure when combined with bupropion. These include other antidepressants, antipsychotics, theophylline, isoniazid, tramadol, stimulants, steroids, hypoglycemic agents including insulin , certain antibiotics e. These medications can change the way your body reacts to bupropion. Bupropion can change the way your body reacts to these medications. Sleep, energy, or appetite may show some improvement within the first weeks.
Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in actiities may need up to weeks to fully improve.
Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs. In short-term studies, antidepressants increased the risk of suicidality in children, adolescents and young adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age Adults ages 65 and older taking antidepressants have a decreased risk of suicidality.
Patients, their families and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. All patients being treated with antidepressants for any indication should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
Last Updated: January This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions.
Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. Search Close Menu. Sign In About Mental Illness.
About Mental Illness Treatments. About Mental Illness Research. Your Journey Individuals with Mental Illness. Your Journey Family Members and Caregivers. Your Journey Identity and Cultural Dimensions. Your Journey Frontline Professionals. Get Involved Become a Fundraiser. You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:. You may need to have blood tests during your treatment with this drug.
The cost of these tests will depend on your insurance coverage. Many insurance companies require a prior authorization for certain brands of this drug. This means your doctor may need to get approval from your insurance company before your insurance company will pay for the prescription.
There are other drugs available to treat your condition. Some may be better suited for you than others. Talk with your doctor about other drug options that may work for you. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional.
You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained here in is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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Many medications can help treat depression. If you're curious about your options, check out this list of antidepressants. Health Conditions Discover Plan Connect. Bupropion, Oral Tablet. Important warnings About Side effects Interactions Other warnings Dosage Take as directed Important considerations Alternatives Highlights for bupropion Bupropion oral tablet is available as brand-name drugs and as generic drugs.
Bupropion comes only as an immediate-release tablet or an extended-release tablet. Important warnings.
What is bupropion? Bupropion side effects. Bupropion may interact with other medications. Bupropion warnings.
How to take bupropion. Take as directed. Important considerations for taking bupropion. Are there any alternatives? How to Help Someone with Depression. There is no fixed length of time for using it, but the patient may be advised to continue taking it, even when they feel better, to prevent the symptoms from recurring. Patients with major depressive disorder who do not respond fully to SSRIs are sometimes prescribed Wellbutrin as an additional medication.
Bupropion has been found to significantly reduce nicotine cravings. A course of treatment normally takes 7 to 12 weeks, but by day 10, the individual has often stopped smoking.
A person who wants to stop smoking may be prescribed a mg tablet of Zyban, or possibly Chantix, twice a day. It is best to use it without nicotine replacement therapy NRT. In the first days after starting treatment, the person may experience agitation, restlessness, and insomnia. Reducing the dose temporarily or avoiding bedtime doses may help relieve sleeping problems.
Around 1 in 1, people who use Wellbutrin are at risk of a seizure. Wellbutrin is not suitable for people who are susceptible to seizures, as it can lower the seizure threshold, making it easier for a seizure to occur. Anyone who has a seizure while using Wellbutrin should stop taking the medication and inform their doctor.
Psychological effects may occur, such as feeling restless or hostile or experiencing delusions or a sense of depersonalization. A risk of suicidal thinking and behavior has been linked to the use of several antidepressants, but it is not clear that the drugs increase the risk. The patient should be monitored for any worsening of the symptoms of depression. For more detail on the different adverse effects, it is important to read the patient information leaflet online or inside the packaging.
Wellbutrin may not be suitable for people with:. Monoamine oxidase inhibitors MAOIs are also used to treat depression. If taken together, side effects may include confusion, restlessness, stomach discomfort or pain, high body temperature, dangerously high blood pressure, leading to headaches, dizziness, and blurred vision, and an increased risk of convulsions. Wellbutrin should not be taken within 2 weeks of stopping MAOIs.
When used to help people stop smoking, bupropion is sold as Zyban or Chantix. The Food and Drug Administration FDA warns that people who are taking one of these drugs to stop smoking must not take the same drug under another name to treat depression. This will increase the dose of the same ingredients, and it may raise the risk of seizures.
Ritonavir or efavirenz are used to treat HIV infection. These can reduce the effects of Wellbutrin. People with liver problems should discuss with their doctor whether or not Wellbutrin is suitable, before taking it. A severe allergic reaction known as anaphylaxis can occur if a person has an allergy to any of the ingredients in Wellbutrin.
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