The "normal" cells will grow back and be healthy but in the meantime, side effects occur. Different drugs may affect different parts of the body. Capecitabine belongs to the category of chemotherapy called antimetabolites.
Antimetabolites are very similar to normal substances within the cell. When the cells incorporate these substances into the cellular metabolism, they are unable to divide. Antimetabolites are cell-cycle specific. They attack cells at very specific phases in the cycle. Antimetabolites are classified according to the substances with which they interfere.
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For information about the 4th Angel Mentoring Program visit www. Toggle navigation. Spanish About Chemocare. Drug Type: Capecitabine is an anti-cancer "antineoplastic" or "cytotoxic" chemotherapy drug. What Capecitabine Is Used For: Colon or rectal cancer Metastatic breast cancer Esophageal, gastric, hepatobiliary, neuroendocrine, pancreatic, ovarian, fallopian tube, peritoneal or unknown primary cancers off-label use Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.
How Capecitabine Is Given: Taken as a pill by mouth. Take after food within 30 minutes of a meal with water. Usually taken in a divided dose 12 hours apart. Tablets come in 2 sizes; mg and mg. Do not crush, chew or dissolve tablets. If you miss a dose, skip the missed dose and go back to your normal time.
Do not take 2 doses at the same time or extra doses. Side Effects: Important things to remember about the side effects of capecitabine: Most people will not experience all of the capecitabine side effects listed. Capecitabine side effects are often predictable in terms of their onset, duration, and severity.
Capecitabine side effects will improve after therapy is complete. Capecitabine side effects may be quite manageable. There are many options to minimize or prevent the side effects of capecitabine. Usually mild, has started as early as 2 weeks after start of treatment. When To Contact Your Doctor or Health Care Provider: Contact your health care provider immediately, day or night, if you should experience any of the following symptoms: Fever of Contact your health care provider within 24 hours of noticing any of the following: Nausea interferes with ability to eat and unrelieved with prescribed medication.
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This content does not have an English version. This content does not have an Arabic version. When is capecitabine given? Before starting capecitabine 4.
How is capecitabine taken? Side effects of capecitabine 6. Other important information 7. Further support. Capecitabine is a chemotherapy drug. Capecitabine is the non-branded name of the drug, but you may also hear it called by its brand name Xeloda.
Studies have shown that some people with primary breast cancer may benefit from capecitabine. This includes people with breast cancer that is triple negative. People who have chemotherapy before surgery may be offered capecitabine after their surgery. Capecitabine may be offered as part of a clinical trial. Before starting your treatment many hospitals will arrange a chemotherapy information session.
You should have blood tests and some people will have an ECG electrocardiogram , a simple test that checks your heart rhythm. Your height and weight will also be measured, to work out the correct dose of chemotherapy for you. You usually take the capecitabine tablets twice a day in the morning and evening for 14 days and then have a 7-day break from taking the tablets. This day period is one treatment cycle. Capecitabine is available in two different tablet strengths: mg or mg.
If you miss a dose of capecitabine, do not take an extra dose to make up for the one you missed. Take the next dose at the usual time and speak to someone in your treatment team. Most people tolerate capecitabine well as the side effects are often mild and can usually be controlled. However, everyone reacts differently to drugs. Some people have more side effects than others, and the side effects described here will not affect everyone.
Your specialist can reduce or delay the dose of capecitabine you take if the side effects become too severe. Reducing the dose of capecitabine is common and the treatment can still be effective at a lower dose. Blood is made up of red cells, white cells and platelets. If the number of blood cells is too low, your next cycle of treatment may be delayed or the dose of chemotherapy reduced. Your treatment team may give you guidelines to follow for reporting signs of an infection, but generally you should contact your hospital immediately if you experience any of the following:.
Before starting chemotherapy you should be given a hour contact number or told where to get emergency care by your treatment team. You may need antibiotics. Sometimes your doctor may recommend injections of drugs called growth factors.
This helps the body produce more white blood cells to reduce your risk of infection. Having too few red blood cells is called anaemia.
If you feel particularly tired, breathless or dizzy, let your treatment team know. Capecitabine can reduce the number of platelets, which help the blood to clot. You may bruise more easily, have nosebleeds or your gums may bleed when you brush your teeth. Tell your treatment team if you experience any of these symptoms. Tell your chemotherapy nurse or treatment team as they can prescribe medication and may consider stopping your capecitabine for a time to help control it.
Hand-foot syndrome, often called Palmar-Plantar syndrome , is a common side effect of some chemotherapy drugs used to treat breast cancer. The palms of the hands and the soles of the feet can become red and sore. Sometimes you may also notice a tingling sensation, numbness or some swelling. The skin on your hands and feet may also become red, dry and flaky. This should improve if the treatment is delayed or if the dose is reduced.
Although most people will not be sick vomit , anti-sickness drugs can help reduce or stop this happening, so take these as prescribed. Steroids may also be given to make the anti-sickness drugs work more effectively.
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